Ketamine, originally developed as an anesthetic, has a long record of safe use in sub-anesthetic doses for management of pain in patients with serious medical illness, and is readily available for clinical use. There is a substantial body of evidence for the use of ketamine in the treatment of refractory depression, leading to FDA-approval of intranasal esketamine for treatment-resistant depression. At sub-anesthetic doses, ketamine is capable of inducing a non-ordinary state of consciousness that is also being studied in the psychedelic-assisted therapies framework. There is a growing body of evidence for KAP’s effective use in treating a variety of mental health disorders. Our team is developing a first-of-its-kind ketamine-assisted psychotherapy clinical service in which patients will receive IV ketamine infusions alongside psychotherapeutic support from clinicians trained in psychedelic-assisted therapies. |